COVID-19 at Any Time During Pregnancy Boosts Mother’s Risk of Death

Open pooled data analysis of international evidence that COVID-19 infection at any time during pregnancy increases maternal mortality risk and causes severe illness in both mother and her newborn Published in Access Journal. BMJ Global Health.

The findings highlight the need for global efforts to minimize the risk of these infections during pregnancy through targeted vaccination campaigns and other protective measures, the researchers said. says.

There is a growing body of research on COVID-19 infection during pregnancy. However, substantial differences in study designs, methods, and comparison groups make it difficult to reach firm conclusions, and few studies have been conducted in low-income countries, researchers say.

The researchers formed an international consortium in April 2020 to obtain high-quality prospective data from relevant studies conducted in several countries, and to circumvent problems associated with previous studies. applied an analytical approach.

The current study, which includes the results of the first individual-level pooled data analysis of these studies, assesses the risk of ill-health and death in pregnant women with confirmed or probable COVID-19 infection. I’m here.

This analysis is based on participants in 12 studies of 13,136 pregnant women from Ghana, Hong Kong China, Italy, Kenya, Nigeria, South Africa, Spain, Sweden, Democratic Republic of the Congo, Turkey, Uganda, and the United States. .

Pregnant women infected with SARS-CoV-2, the virus that causes COVID-19 infection, have been shown to be nearly eight times more likely to die than uninfected women.

They were also nearly four times more likely to need intensive care. 15 times more likely to require artificial respiration. He’s also five times more likely to need any kind of critical care.

They were also 23 times more likely to be diagnosed with pneumonia and more than 5 times more likely to have a serious blood clot.

Babies born to women with COVID-19 were almost twice as likely to be admitted to a neonatal care unit. Almost three times more likely to be born moderately premature (less than 34 weeks). She is also 19% more likely to be underweight at birth than a baby born to an uninfected woman.

However, unlike findings in previous reviews, COVID-19 infection was not associated with increased risk of stillbirth or restricted growth after 28 weeks of gestation.

The researchers point to some limitations of their study. Choices for pregnant women with COVID-19 depend on when and how they were tested for SARS-CoV-2. This has changed over time across sites with the availability of test kits. This analysis did not consider the different impacts of SARS-CoV-2 variants that have emerged since the beginning of the pandemic. Some results were not monitored for any clinically meaningful time period.

Despite these warnings, “these findings highlight the need for global efforts to prevent COVID-19 during pregnancy through targeted administration of vaccines and non-pharmaceutical interventions.” ‘ said the researchers.

This is particularly important because “global guidance is vague about the potential risks of infection and the benefits and safety of vaccination, and more than 80 countries now recommend that all pregnant and lactating women be vaccinated.” We do not recommend that you receive

This news release was published by BMJ on January 16, 2023.

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