Sleep, shift work not associated with fecundability, live birth after pregnancy loss

January 13, 2023

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Freeman does not report related financial disclosures. See research for relevant financial disclosures of all other authors.

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For women trying to conceive after one or two miscarriages, sleep duration, sleep duration, and shift work were not associated with fertility or fertility. Fertility and Infertility show.

According to research background, sleep is increasingly thought to be a key factor in fertility and fertility due to its potential role in regulating reproductive hormones.

Sleep duration, sleep timing, social jet lag, and shift work were not associated with fertility or fertility.Source: Shutterstock

“Furthermore, because intermediates of the sleep-wake cycle (melatonin and clock genes) are found in the ovary and uterus, they are involved in ovulation, embryo implantation during establishment of pregnancy, and early pregnancy through mechanisms of placental development and decidualization.” may have.” Dr. Joshua R. Freeman, M.P.H., Written by Eunice Kennedy Shriver, postdoctoral fellow in the Division of Metabolic Epidemiology at the National Institute of Child Health and Human Development, and colleagues.

“Given the limited evidence on sleep characteristics, fertility, and birth, our aim was to determine sleep duration, It was to assess the timing of sleep, the role of shift work, one or two miscarriages,” they wrote.


Freeman et al. conducted a secondary analysis of the Effects of Aspirin on Pregnancy and Reproduction (EAGeR) trial. The EAGeR trial enrolled women aged 18 to 40 years living in Utah, New York, Pennsylvania, or Colorado who had one or two miscarriages and were actively trying to conceive. Participants were followed for up to six menstrual cycles while trying to conceive. Pregnant women were followed throughout their pregnancy.

Typical participant-reported bedtime, wake-up time, and sleep onset latency at baseline were used to calculate sleep duration, sleep midpoint. “Sleep debt incurred on weekdays” — social jet lag defined as the difference in sleep hours between weekdays and weekends. School schedule was not available.

fertility, birth

The final analysis of fertility and live birth included 1,220 women who completed a baseline sleep questionnaire. Of these, 476 (39%) reported her 7–8 hours of sleep. Most of the women worked non-rotating shifts (n = 973) and no night shifts (n = 903), sleeping at the halfway point before 5am.

Women who slept 9 or more hours versus 7-8 hours and those whose sleep midpoint was between tertiles 3 (midpoint, 4:40 a.m.) and 2 (midpoint, 3:36 a.m.) and there was no significant difference in fertility. Social jet lag and night shifts were also not associated with fertility.

A sensitivity analysis that excluded shift workers revealed a strong association between sleep duration and fertility. Women who slept more than 9 hours had lower fertility rates compared with women who slept 7 hours to her 8 hours (OR = 0.62; 95% CI 0.42-0.93).

“Separately, the hourly increase in social jet lag was greater at lower fertility among women who had three or more cycles of pregnancy attempts prior to study entry.” writes Freeman and colleagues.

There were 596 live births in the cohort. Analysis showed that preconception sleep duration, sleep timing, and shift work were not associated with fertility.

Moving forward, Freeman and colleagues emphasized the need for studies specifically designed to assess the effects of sleep on fertility and live birth in large cohorts.

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